United Pharmacies (UK) provides a wide range of brand name and generic medications at prices far cheaper your local pharmacy! Mylan manufactures FINASTERIDE Tablets, USP (Proscar) in strengths of 1 mg5 mg. ยท PROSCAR 5mg TABLETS (finasteride) Your medicine is known by above names but will be referred to as. United Kingdom: Yellow Card Scheme at. Minoxidilmax is a leading supplier for professional hair regrowth products. 10% with finasteride. We will not store your credit card or any other sensitive. Finasteride: dosage, frequency & conception. I posted the following in another thread, but I thought it might be helpful as its own topic. This info is floating around in bits & pieces all over this forum, but collecting it all in one place may be useful. In human clinical trials, the pharmacokinetic half- life of finasteride was found to be 6 - 8 hours. However, the pharmacodynamic lifetime of finasteride action, measured in terms of the drug's ability to reduce the systemic concentration of DHT, after a single oral dose of between 0. See the first chart below (taken from the book entitled, Integration of Pharmaceutical Discovery and Development: Case Histories): You can see how a single dose of the drug reduces the systemic concentration of DHT over a 7 day period. That leads one to believe that taking finasteride daily is probably not necessary to maintain one's hair count. However, it also leads one to believe that taking one dose every 5 - 7 days is probably unwise as well, because while the DHT remains reduced over the 7 day period it does slowly rise over that time. A finasterida impede que a enzima 5-alfa-redutase tipo II converta a testosterona em dihidrotestosterona. Visa Electron e Mastercard). United Kingdom. Finasteride 1 mg Film-coated Tablets. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme. United Kingdom. 8. Fincar (Generic Proscar) Add. Buy Finasteride (Propecia) Online - Pharmacy2Home.com. Pay us through debit/credit card and have the drugs delivered at your. Fincar (finasteride) is used to treat benign prostatic hyperplasia (BPH or enlarged prostate) and hair loss in men and you can buy Fincar 5mg tablets online from. Then the question is how often should one take finasteride? Based on the above chart, I'd say it would probably be pretty safe to take it every other day or even three times a week (MWF). You may even get away with twice a week (MTh). The next question is how much (as in mg) should one take? Take a look at the charts below (the first three charts are from a Propecia study story (circa 1. Sherman Frankel, a University of Pennsylvania professor of physics): You can see from the Serum DHT graph above that from doses of 0. DHT was about the same. You can see from the Scalp Skin DHT graph above that from doses of 0. DHT was about the same. You can see by the above graph that the dose dependence appears also in the accompanying rise in T, one- onehundredth the 5 mg dose being identical in its effect on the scalp skin testosterone. The above graph (origin unknown) indicates how the following dosages of finasteride inhibit DHT: - 0. All pretty close in terms of percentages.__________________________________________________ __________________________I'm no scientist, but the first plasma DHT graph seems somewhat at odds with the rest of the graphs: - 0. DHT to ~ 5. 5 ng/dl- 0. Patient information for FINASTERIDE 1MG TABLETS Including dosage. Finasteride is used for the treatment. United Kingdom: Yellow Card Scheme at www.mhra. DHT to ~ 4. 2 ng/dl- 1. DHT to ~ 3. 2 ng/dl- 5. DHT to ~ 2. 5 ng/dl The first graph deals in blood serum levels. The rest in percentages of inhibited DHT. Unfortunately, I'm not sure how to compare the two. Zara United KingdomPerhaps plasma DHT levels of 5. MPB? I welcome others more expert in these matters to chime in. Regardless, I conclude: It's probably pretty safe to take finasteride every other day or even three times a week (MWF). You may even get away with twice a week (MTh). Dosage is a matter of personal experimentation. Merck recommends 1mg daily for optimal results. Maybe they are right, but when you consider the above information; the personal testimonials of many forum members who have successfully reduced dosages; and, the fact that Merck is a pharmaceutical company interested primarily in profits, then I think a healthy bit of skepticism is warranted. If you want to save money and/or reduce side effects, I'd suggest tapering down slowly, and paying very close attention to any changes, until you reach a regimen which preserves your hair and eliminates sides. Keep a hair loss journal complete with weekly photos if it helps. Perhaps something like this (if you're splitting 1mg Propecia tablets): - 1mg every other day for one month. If still experiencing sides, but not losing hair, then - - 1mg MWF for one month. If still experiencing sides, but not losing hair, then - - 1mg TTh for one month. If still experiencing sides, but not losing hair, then - - 0. MWF for one month. If still experiencing sides, but not losing hair, then - - 0. TTh for one month. If still experiencing sides, but not losing hair, then - - 0. MWF for one month. If still experiencing sides, but not losing hair, then - - 0. TTh for one month. If still experiencing sides, stop the meds. If one month at each dosage doesn't work for you, adjust to a time period which does. Obviously, if you start losing hair anytime during the tapering- off period, then you've gone too low and you have an important decision to make - do I up the meds again to preservation levels and deal with sides or just stop completely? Only you can answer that.__________________________________________________ _______________Regarding finasteride and conceiving children. I am aware of no evidence that men taking finasteride while trying to conceive will cause birth defects. Here is some information to consider according to Dr. Richard Lee: - "In rabbit fetuses exposed to finasteride in utero from days 6- 1. This result would be expected, since there was no exposure during the critical period of genital system development in rabbits."- "When pregnant rhesus monkeys were given intravenous finasteride at a level equivalent to at least 7. In the human embryo, the sensitive period of external genitalia development is during the 7th - 9th weeks of gestation. Although the chromosomal and genetic sex of an embryo is determined at fertilization by the kind of sperm, either Y- bearing or X- bearing, that fertilizes the ovum, male and female morphological characteristics do not begin to develop until the seventh week.. Since the sensitive period of development of the external genitalia in the human embryo is the 7th to 9th weeks of gestation, there can be no danger to the child if the father is taking finasteride at the time of conception. Originally, Merck decided to err on the side of caution and warned against the possible problem of finasteride transfer in semen. This warning has since been removed from the package insert. Considering the medical/legal implications of a theoretically possible link of finasteride treatment to birth defects, it is reasonable to assume that Merck & Co. Nor is there any evidence of birth defects when the father taking finasteride has intercourse with the pregnant mother during the critical periods of sexual development. The in utero effects of finasteride exposure during the period of embryonic and fetal development (gestation days 2. Intravenous administration of finasteride to pregnant monkeys at doses as high as 8. Still, Merck retains this admonition: "Women should not handle crushed or broken Propecia tablets when they are pregnant or may be potentially pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Propecia tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed."- "Considering that intravenous administration of finasteride to pregnant experimental animals during the critical periods of sexual development didn't cause birth defects, there is no reason to believe that transdermal absorption of finasteride from handling broken tablets could cause birth defects in the male child. But, since Propecia has not been approved by the FDA for use by women, Merck has nothing to lose by retaining this warning. In fact, it has good p. So, can finasteride cause birth defects? Yes, there is a theoretical possibility that it can, but the probability is close to nil, when finasteride is taken in the recommended dosages. Since Propecia was approved by the FDA on 2. December 1. 99. 7 and Proscar on 2. August 1. 99. 6, millions of doses of finasteride have been taken and there has not been a single case report of a birth defect. Now that's reassuring information."- "We do caution men who desire to father children to discontinue finasteride use two week prior to planned conception. Actually, there have been no reports of birth defects due to taking finasteride. But because birth defects can occur in women who have a DHT deficiency, the warning is mandated by the FDA for the 5mg. Despite the above information, some guys (and their significant others) are still concerned about it. Something to keep in mind is the half- life for dissociation of the inhibitory complex between finasteride and its enzyme target is in excess of 3. Half- life is defined as "the time required for something to fall to half its initial value." So, it works out something like this: Day 1 - 1. Day 3. 0 - 5. 0%Day 6. Day 9. 0 - 1. 2. 5%Day 1. Day 1. 50 - 3. 1. Day 1. 80 - 1. 5. And, so on.. So, at 6 months you still have around 1. That's also something to keep in mind regarding how long side effects can last for the average man (nevermind those who are genetically predisposed to severe side effects). So, obviously, I don't know if or how finasteride could affect conception via semen. But if it can (which is what some are worried about), then discontinuing finasteride 2 weeks prior to planned conception, as Dr. Lee (and the FDA) prescribes, may not make much of a difference - it doesn't appear to be enough time. Unless the two week rule has something to do with the pharmacokinetic half- life or the pharmacodynamic lifetime of finasteride action, both being much shorter? If you have evidence that stopping for two weeks makes a difference, please present it. Based on the evidence thus far, it seems to me if you're going to stop for conception purposes, stop for the long- term, or don't bother at all. And, if you're going to stop for conception purposes, once your lady is pregnant, wear a condom for the duration of the pregnancy. Lastly, there's little doubt that after the first month of discontinuation you will be losing hair that finasteride was preserving for you, so weigh the decision carefully. Last edited by zenmunk; 0.
2 Comments
Lutheran Hospital
7/8/2019 03:04:25 am
Este es un anuncio público para todos los que deseen vender un riñón. Tenemos pacientes que necesitan un trasplante de riñón. Si está interesado en vender un riñón, contáctenos en nuestro correo electrónico [email protected]
Reply
Lutheran Hospital
2/4/2020 05:23:51 am
Estamos buscando donantes de riñón serios mayores de 18 años que estén interesados en vender un riñón para salvar una vida y tenemos una buena oferta y otras compensaciones para cada donante.
Reply
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |